Decontaminating N95 Masks with Steam Sterilization Written by: Amit Gupta Can N95 Masks be steam sterilized for reuse? This article attempts to answer this question by giving a review of the current literature and taking a closer look at N95 filter types and materials of construction. The ability to autoclave N95 masks would be ideal because autoclaving is a proven sterilization process and existing autoclave […] Tweet Like Share
An Automated Autoclave Process for Use in Determining Glassware Quality [USP 660] Written by: Amit Gupta Glass containers for pharmaceutical use are intended to come into direct contact with pharmaceutical products. The glass container manufacturing process directly results in the quality of glass produced. Certain types of glass are less durable than others and are therefore more susceptible to delamination of the interior of the glass container. If delamination occurs on […] Tweet Like Share
What Is the Difference Between Laboratory, GLP, and GMP Steam Sterilizers? Written by: Amit Gupta Good Manufacturing Practice (GMP) sterilizers are required for any sterilization that directly supports the manufacture or testing of human-use drug products. Good Laboratory Practice (GLP) sterilizers meet a relaxed subset of those same requirements and are appropriate for pre-clinical research. Basic laboratory sterilizers are sufficient for everything else — waste, animal testing, and general research […] Tweet Like Share
Your Guide to the ATF Bioreactor Sterilization Cycle Written by: Amit Gupta The ATF Bioreactor Cycle is designed to permit the sterilization of hollow fiber filters while housed in bioreactors such as those made by Repligen and Spectrum Labs. This cycle is a relatively new addition to the typical list of sterilization cycles normally found in laboratory autoclaves. Below is an explanation of the ATF Bioreactor Sterilization […] Tweet Like Share
Sterilization 101: How Does a Laboratory Autoclave Work? Written by: Amit Gupta Steam sterilization is an important process, one that is performed in every laboratory. In this article, we will explore the history of steam sterilization, how a sterilizer works, and emerging trends in sterilizer design. Key Takeaways: The terms “autoclave” and “steam sterilizer” are interchangeable. Steam is a far more efficient heat transfer medium than air […] Tweet Like Share
What to Know About Sterilizer Manufacturers When Designing a Laboratory Written by: Amit Gupta Designing a laboratory requires an incredible amount of forethought, knowledge, and planning. Not only must architects properly lay out the floor plan for the equipment, but they must also ensure the specifications for the equipment are accurate. The more complex the equipment (e.g. an autoclave) the more challenging these design efforts can be. From the […] Tweet Like Share
How to Validate an Autoclave: Performance Qualification (PQ) Written by: Amit Gupta An autoclave undergoes qualification testing in order to validate and verify that it’s performing consistently and properly. In previous posts, we outlined the first two qualification tests known as Installation Qualification (IQ) and Operation Qualification (OQ). In this post we will review Performance Qualification (PQ) as a final critical step in validating your autoclave. What […] Tweet Like Share
Autoclave Chamber Material: Stainless Steel vs Nickel-Clad Written by: Amit Gupta Current, state-of-the-art laboratory autoclave chambers are manufactured using stainless steel. In the past, autoclave manufacturers constructed sterilizers using nickel-clad, a highly corrosion-resistant material. The industry has shifted due to the rising cost of “cladding” over the last 10-15 years, heading in the direction of primarily 316L stainless steel. Why should you care? Because while stainless […] Tweet Like Share
How To Validate an Autoclave: Operational Qualification (OQ) Written by: Amit Gupta Every laboratory strives for consistency and repeatability in its sterilization processes. But this doesn’t come easily. In order to ensure your autoclave operates efficiently it’s critical that you validate the sterilization process and verify that the equipment is working safely and properly. This is known as Operational Qualification (OQ), and it’s one of the most […] Tweet Like Share
How To Validate an Autoclave: Installation Qualification (IQ) Written by: Amit Gupta There is an array of qualification tests that can be conducted to validate an autoclave. Many laboratories validate autoclaves by simply using biological indicators (BI’s). For some labs, however, a simple validation with BI’s is not enough and a more elaborate validation process must be followed. These labs typically require installation, operation, and performance qualifications […] Tweet Like Share
12.10.25 Introducing SterilSteam Sampler, The Steam Condensate Sampler for AAMI ST108 Compliance → Released in 2023, AAMI/ANSI ST108 establishes water quality requirements for water used in the cleaning, rinsing, disinfection, and sterilization of reusable medical devices. In addition to these requirements, ST108 mandates quarterly testing of steam condensate quality to ensure incoming steam does not stain instruments or pose a risk to patient safety. To help healthcare facilities […]
11.6.25 AAMI ST108 & Critical Water for Autoclaves: What ASCs Need to Know → A major step forward in patient safety, ANSI/AAMI ST108 establishes new minimum water quality requirements for water used in the cleaning, rinsing, disinfection, and sterilization of reusable medical devices. Despite providing guidance on water quality management for sterile processing, ST108 has also created confusion, especially regarding test protocols, water treatment, and critical water requirements. In […]
10.20.25 What Is an Autoclave Machine Really Used for? [Applications, Costs & More] → Autoclave machines are mission-critical equipment in a variety of industries, from healthcare to biotech, ensuring equipment and materials are sterilized and safe for use. Whether you’re considering purchasing an autoclave for a new facility, replacing a broken one, or expanding your current sterilization capacity, understanding the ins and outs of autoclave technology is key to […]
