Sterilization Cycle Development

How to Validate an Autoclave: Sterilization Cycle Development

Cycle development is an important part of both the autoclave procurement and validation processes. In previous posts about validation, we explored Installation Qualification (IQ), Operation Qualification (OQ), and Performance Qualification (PQ). We also discussed the importance of steam quality testing as part of validating your autoclave, as well…

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How to sterilize

The Challenge of Prion Sterilization

Transmission of prion diseases through medical equipment remains an ever-present possibility in many laboratories and medical facilities throughout the world today—and as such, should not be taken lightly. Facilities that lack definitive prion sterilization protocols for exposed medical equipment put…

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Immediate-Use Flash Sterilization Cycle Autoclave

Laboratory Autoclave Steam Sterilization Cycles, Part 10: Immediate-Use (Flash) Sterilization Cycle

There has been much debate around the antiquated term “flash sterilization.” A concerted effort has been made by the Association for Advancement of Medical Instrumentation (AAMI), the Joint Commission (JC) and the Food and Drug Administration (FDA), to clarify the use of flash sterilization, which these organizations now refer to as “immediate use” sterilization. This sterilization cycle is not intended for routine instrument sterilization but only when specific instruments are needed for an emergency procedure. Read more →

Laboratory Autoclave Steam Sterilization Cycles, Part 9: Air Over-Pressure Cycle

Laboratory Autoclave Steam Sterilization Cycles, Part 9: Air Over-Pressure Cycle

In the ninth installment of our Steam Sterilization Cycles Series, we explore Air Over–Pressure, another cycle used to sterilize a specific type of liquid load. An Air Over-Pressure Cycle is used to sterilize small liquid loads that are extremely sensitive to evaporation or boil-over in laboratory autoclaves. Typical applications for this cycle include pre-filled pipet tips, small pre-filled vials, loosely capped flasks, foil sealed glassware, or any partially vented containers where even small amounts of evaporation are not acceptable. Read more →

Steam Sterilization Cycles, Part 7: Product Lifecycle Testing in an Autoclave

Steam Sterilization Cycles, Part 7: Product Lifecycle Testing in an Autoclave

In our 7th installment of the Advanced Cycles Series, we explore automated product lifecycle testing in an autoclave. Repeated exposure to an autoclave chamber’s extreme temperature and pressure conditions allows Quality Control Specialists to sharply accelerate product aging and evaluate the lifecycle of a product. Typically, this process requires that an individual (e.g. technician, scientist, engineer, etc) spend countless hours in front of an autoclave. What if you could program the autoclave to run multiple sterilization cycles (over multiple hours or days) with the press of a single button? Read more →

Steam Sterilization Cycles, Part 4: Rapid Cool Cycles

Steam Sterilization Cycles, Part 5: Low Temperature Cycle

Steam sterilizers play a pivotal role in your lab’s research capabilities and throughput. However, how can you safely and properly sterilize load types that are more temperature-sensitive than others? To help you avoid overheating a specific load type, thereby compromising it, we introduce the fifth article in CSS’ ongoing Steam Sterilization Cycles series:  Read more →